Description
Product Characteristics: Protein kinase C ('PKC', EC 2.7.11.13) is a cyclic, nucleotide-independent enzyme that phosphorylates serine and threonine residues. The'PKC'amily is divided into three groups depending on each the enzymes' cofactor requirements: conventional (c'PKC'soforms (alpha, betaI, betaII, and gamma) require diacylglycerol (DAG), Ca2+, and phospholipids for activation, novel (n'PKC'soforms (delta, epsilon, eta (also known as PKC-L), Theta, and µthe mouse homolog of human PKCµ(also known as PKD)) require DAG but not Ca2+ for activation, and atypical (a'PKC'soforms, (zeta, iota, and lambda, the mouse homolog of human'PKC'ota) require neither Ca2+ nor DAG. A new'PKC'ember has recently been discovered and is referred to as PKCnu.PKC's phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. These kinases also serve as major receptors for phorbol esters, a class of tumor promoters. Every member of the'PKC'amily has a specific expression profile and is believed to play a distinct role in cells.PKCµ, also known as nPKC-D1 and nPKC-mu, is a member of'PKC'amily of serine/threonine kinases. PKCµ has two characteristic cysteine-rich repeats, a conserved ATP-binding consensus sequence in the kinase domain, and the invariate aspartate essential for kinase activity.Rabbit Anti-PKCµ Polyclonal Antibody is developed in rabbit using a KLH-coupled synthetic peptide corresponding to residues of human PKCµ protein.
Target Information: Please see product details or send an inquiry to antibodies-online for additional target information