Description
Product Characteristics:
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
Subcellular location: Secreted
Synonyms: Acylation stimulating protein, ASP, C3, C3a anaphylatoxin, Complement C3 alpha chain, Complement C3, Complement C3 precursor, Complement component 3, Complement component C3, Complement factor 3, Plp, Complement C3dg fragment, CO3_HUMAN.
Target Information: Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection. [provided by RefSeq, Feb 2009]