Description
Product Characteristics:
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
Subcellular location: Cytoplasm, Cell membrane
Synonyms: 3 dehydrosphinganine reductase, 3 ketodihydrosphingosine reductase, 3-dehydrosphinganine reductase, 3-ketodihydrosphingosine reductase, DHSR, FLJ36555, FLJ92680, Follicular lymphoma variant translocation 1, Follicular variant translocation protein 1, FVT 1, FVT-1, FVT1, KDS reductase, KDSR, KDSR_HUMAN, SDR35C1, Short chain dehydrogenase/reductase family 35C member 1.
Target Information: The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]