Description
Product Characteristics:
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
Subcellular location: Cytoplasm
Synonyms: 114 kDa Rho specic guanine nucleotide exchange factor, ARHGEF 18, ARHGEF18, KIAA0521, MGC15913, p114 Rho GEF, p114-Rho-GEF, Rho specic guanine nucleotide exchange factor p114, Rho-specic guanine nucleotide exchange factor p114, Rho/Rac guanine nucleotide exchange factor GEF 18, Rho/Rac guanine nucleotide exchange factor 18, SA RhoGEF, Septin associated RhoGEF, ARHGI_HUMAN.
Target Information: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]