Description
Product Characteristics:
NP60 is a 553 amino acid nuclear protein that regulates the phosphorylation and activation of p38 alpha in response to stress. There are five isoforms of NP60 that are produced as a result of alternative splicing events.
Subcellular location: Nucleus
Synonyms: 3 hydroxyisobutyrate dehydrogenase like protein, 3-hydroxyisobutyrate dehydrogenase-like protein, BM045, Cytokine like nuclear factor n pac, Cytokine-like nuclear factor N-PAC, Glyoxylate reductase 1 homolog, GLYR1, GLYR1_HUMAN, HIBDL, N-PAC, NP60, Nuclear protein 60 kDa, Nuclear protein NP60, Nuclear protein of 60 kDa, Putative oxidoreductase GLYR1.
Target Information: May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) (By similarity)