Description
Product Characteristics:
Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors (1). Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein alpha, Beta and Gamma polypeptides are encoded by at least 16, 4 and 7 genes, respectively (2-5). Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of G alpha subunits have been identified, these include Gs, Gi, Gq and Ga 12/13 (3,4). The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Ga i-1, Ga i-2, Ga i-3, Ga o, Ga t1, Ga t2, Ga z and Ga gust (4). Of these, the three Ga i subtypes function to open atrial potassium channels (6). Ga 16 is a member of the Gq subfamily and is expressed specifically in hematopoietic cells (7).
Subcellular location: Cell membrane
Synonyms: G alpha 15, G alpha 16, G alpha-15, G alpha-16, G-protein subunit alpha-15, G-protein subunit alpha-16, GNA 15, GNA 16, GNA15, GNA15_HUMAN, GNA16, Gq class, Guanine nucleotide binding protein alpha 15, Guanine nucleotide binding protein alpha 15 subunit, Guanine nucleotide-binding protein subunit alpha-15, Guanine nucleotide-binding protein subunit alpha-16.
Target Information: alpha subunit of an heterotrimeric G-protein, may function in taste signal transduction