Description
Product Characteristics:
KLF17 binds G/C-rich sites via its zinc fingers and activates transcription from CACCC-box elements. It may be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development.
Subcellular location: Nucleus
Synonyms: FLJ40160, Krueppel like factor 17, Novel zinc finger protein, RP4 675G8.1, RP4675G8.1, Zfp393, Zinc finger protein 393, ZNF393, KLF17_HUMAN, Krueppel-like factor 17.
Target Information: Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity)