Description
Product Characteristics:
Bcl rambo shares common structural characteristics with other members of the anti-apoptotic Bcl2 family members, but differs from them at its C-terminus, where a 250 amino acid sequence preceeds the membrane anchor region. It also differs from other pro-apoptotic Bcl-2 family members in that its membrane anchor C-terminus region is responsible for its apoptotic activity, not its Bcl-2 homology motifs. Bcl rambo may promote the activation of caspase-3 and apoptosis.
Subcellular location: Cytoplasm, Nucleus, Cell membrane
Synonyms: Apoptosis facilitator, Bcl 2 like 13, Bcl 2 like 13 protein, BCL2 like 13 apoptosis facilitator, BCL2 like 13, Bcl2 like 13 protein, BCL2L13, MIL 1, MIL1, MIL1 protein, Protein Mil1, B2L13_HUMAN.
Target Information: This gene encodes a mitochondrially-localized protein with conserved B-cell lymphoma 2 homology motifs. Overexpression of the encoded protein results in apoptosis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]