Description
Product Characteristics:
Folate is an essential vitamin that must be obtained from food intake through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, which mediates the endocytosis of 5-methyltetrahydofolate into the cell.
Synonyms: fetal/placental, Folbp 2, beta hFR, FBP, FBP/PL 1, FBP2, folate receptor 2 fetal, Folate receptor 2, Folate receptor, Folate receptor beta, Folate receptor, fetal/placental, Folbp2, Folr2, FOLR2_HUMAN, FR beta, FR P3, FR-beta, Placental folate binding protein, Placental folate-binding protein.
Target Information: The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]