Description
Product Characteristics:
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Subcellular location: Nucleus
Synonyms: ICA 12, ICA12, Islet cell antibody 12, Islet cell antigen 12, MGC117216, SOX 13, SOX 13 protein, sox13, SOX13 protein, SOX13_HUMAN, SRY Sex determining region Y-box 13, SRY box 13, SRY box containing gene 13, SRY related HMG box gene 13, SRY sex determining region Y box 13, Transcription factor SOX 13, Transcription factor Sox-13, Type 1 diabetes autoantigen, Type 1 diabetes autoantigen ICA 12, Type 1 diabetes autoantigen ICA12.
Target Information: This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. It has also been determined to be a type-1 diabetes autoantigen, also known as islet cell antibody 12. [provided by RefSeq, Jul 2008]