Description
Product Characteristics:
Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Synonyms: 1 alpha 25 dihydroxyvitamin D3 inducible, DDVit 1, DDVIT1, EDAF-1, EDAF1, EDPF-1, EDPF1, Enterocyte dferentiation associated factor EDAF 1, Enterocyte dferentiation promoting factor, Enterocyte dferentiation-associated factor 1, Enterocyte dferentiation-promoting factor 1, Methyl methanesulfonate sensitive 2, MMS 2, MMS2, MMS2 homolog, UB2V2_HUMAN, UBE2V 2, UBE2V2, Ubiquitin conjugating enzyme E2 variant 2, Ubiquitin conjugating enzyme E2v2, Ubiquitin-conjugating enzyme E2 variant 2, UEV 2, UEV2, Vitamin D3 inducible protein, Vitamin D3-inducible protein.
Target Information: Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes. [provided by RefSeq, Jul 2008]