Description
Product Characteristics:
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA R alpha 1-6, GABAA R beta 1-3, GABAA R gamma 1-3, GABAA R gamma, GABAA R delta. The GABAB family is composed of GABAB R1 alpha and GABAB R1 beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.
Subcellular location: Cell membrane
Synonyms: GABA A, GABA A Receptor alpha 6 polypeptide, GABA A receptor alpha 6, GABA A receptor subunit alpha 6, GABA subunit A receptor alpha 6, GABAA receptor subunit alpha-6, GABRA 6, GABRA6, Gamma aminobutyric acid A receptor alpha 6, Gamma aminobutyric acid GABA A receptor alpha 6, Gamma aminobutyric acid receptor subunit alpha 6, Gamma-aminobutyric acid receptor subunit alpha-6, GBRA6_HUMAN, MGC116903, MGC116904.
Target Information: GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]