Description
Product Characteristics:
LRFN1 is a 771 amino acid single-pass type I membrane protein that belongs to the LRFN family. Containing a fibronectin type-III domain, an Ig-like (immunoglobulin-like) domain, a LRRCT domain, a LRRNT domain and seven LRR (leucine-rich) repeats, LRFN1 is thought to promote neurite outgrowth in hippocampal neurons and is involved in the regulation and maintenance of excitatory synapses. LRFN1 forms heteromeric complexes with LRFN2, LRFN3, LFRN4 and LFRN5, but does not have the ability to form homomeric complexes across cell junctions of adjacent cells like other LRFN family members. The PDZ-binding motif of LRFN1 is required for neurite outgrowth promotion and for SAP 97-, NE-dlg- and PSD-95-binding. LRFN1 is encoded by a gene located on human chromosome 19q13.2 and mouse chromosome 7 A3.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Leucine rich repeat and fibronectin type III domain containing 1, Leucine rich repeat and fibronectin type III domain containing protein 1, Leucine-rich repeat and fibronectin type III domain-containing protein 1, LRFN 1, lrfn1, LRFN1_HUMAN, SALM 2, SALM2, Synaptic adhesion like molecule 2, Synaptic adhesion-like molecule 2.
Target Information: Promotes neurite outgrowth in hippocampal neurons (By similarity). Involved in the regulation of the differentiation and maintenance of excitatory synapses. Induces the clustering of excitatory postsynaptic proteins, including DLG4, DLGAP1, GRIA1 and GRIN1