Description
Product Characteristics:
Cyclophilins are conserved, ubiquitous and abundant cytosolic peptidyl-prolyl cis-trans isomerases that accelerate the isomerization of XaaPro peptide bonds and the refolding of proteins. Human cyclophilin A (CyPA), an intracellular protein of 165 amino acids, is the target of cyclosporin A (CsA) and is encoded by a single unique gene conserved from yeast to humans. Cyclophilin B (CyPB) is secreted in biological fluids such as blood or milk and binds to a specific receptor present on the human lymphoblastic cell line Jurkat and on human peripheral blood lymphocytes. Cyclophilin D (CyP40) is a widely expressed cytoplasmic protein that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. It is a widely expressed cytoplasmic protein.
Synonyms: 40 kDa peptidyl prolyl cis trans isomerase, 40 kDa peptidyl prolyl cis trans isomerase D, 40 kDa peptidyl-prolyl cis-trans isomerase, Cyclophilin D, Cyclophilin D, Cyclophilin related protein, Cyclophilin-40, Cyclophilin-related protein, Cyclophilin40, CyclophilinD, CYP 40, CYP 40, CYP-40, CYP40, CYP40, CYPD, CYPD, MGC33096, Peptidyl Prolyl Isomerase D, Peptidyl Prolyl Isomerase D, Peptidyl-prolyl cis-trans isomerase D, Peptidylprolyl isomerase D, PPIase, PPIase D, PPID, PPID, PPID_HUMAN, Rotamase, Rotamase D.
Target Information: The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]