Description
Product Characteristics:
GCX-1 is a 488 amino acid transcription activator that is restricted to expression in the hypothalamus, pituitary, ovary, testis and uterus.Human reproduction is controlled by the hypothalamic-pituitary gonadal axis (HPGA) that is laid down early in fetal development. This expression pattern in the HPGA suggests that this nuclear protein is likely related to specific events in reproduction, particularly in the female. GCX-1 contains a HMG-box domain, which is commonly found in proteins that function as intercellular regulators and transcriptional co-regulators, and are found to be involved in important events such as sex determination and in the regulation of T cell differentiation. There are two isoforms of GCX-1 which are produced as a result of alternative splicing events.
Subcellular location: Nucleus
Synonyms: Chromosome 20 open reading frame 100, Chromosome 20 open reading frame 100, dJ1108D11.2, dJ495O3.1, GCX 1, GCX1, GCX-1, Granulosa cell HMG box protein 1, MGC15880, Weakly similar to NONHISTONE CHROMOSOMAL PROTEIN 6A [S.cerevisiae], Weakly similar to NONHISTONE CHROMOSOMAL PROTEIN 6A [S.cerevisiae], TOX2_HUMAN.
Target Information: acts as a transcriptional activator\, may regulate follicular development and other processes related to female reproduction [RGD, Feb 2006]