Description
Product Characteristics:
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neuro-degeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 to 7. The kainate/AMPA receptors are primarily responsible for fast excitatory neurotransmission by glutamate, whereas the NMDA receptors exhibit slow kinesis of Ca2+ ions and a high permeability for Ca2+ ions. One such NMDA receptor, NR3B, is expressed in motor neurons and forms cation channels impermeable to calcium, which can resist many open-channel blockers. NR3B functions in the brain as an excitatory glycine receptor, modifying the normal role of glycine as an inhibitory neurotransmitter.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Glutamate Receptor Ionotropic N methyl D aspartate 3A, Glutamate Receptor Ionotropic N methyl D aspartate 3B, Glutamate Receptor Ionotropic N-methyl-D-aspartate 3A, Glutamate Receptor Ionotropic N-methyl-D-aspartate 3B, GRIN3A, GRIN3B, NMDA receptor subunit 3A, NMDA receptor subunit 3B, NMDA Type Glutamate Receptor Subunit NR3B Precursor, NMDAR-L, NR3A, NR3B, NMD3B_HUMAN_ NMD3A_HUMAN
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