Description
Product Characteristics:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Subcellular location: Cytoplasm
Synonyms: Chromosome 16 open reading frame 22, F box and leucine rich repeat protein 16, F box/LRR repeat protein 16, F-box and leucine-rich repeat protein 16, F-box/LRR-repeat protein 16, Fbl16, FBXL 16, Fbxl16, Fbxl16 F-box and leucine-rich repeat protein 16, FLJ33735, FXL16_HUMAN, Scirr1, Spinal cord injury and regeneration-related protein 1, BC042620, C16orf22, c380A1.1 novel protein, c380A1.1.
Target Information: Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\, MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]