Description
Product Characteristics:
MPP3, also known as Discs large homolog 3 (DLG3), is a 585 amino acid protein belonging to the MAGUK family. Proteins in the MAGUK family, including CASK, ZO-1, ZO-2, p55 and MPP2, are known to regulate cell proliferation, intracellular junctions and signaling pathways by interacting with the cytoskeleton. MPP3 contains one guanylate kinase-like domain, one PDZ domain, two L27 domains and one SH3 domain. Via the PDZ domain, MMP3 interacts with the C-terminus of TSLC1. MMP3 has also been found to interact with SR-2A and SR-4.
Synonyms: Discs large homolog 3 neuroendocrine dlg, Discs large homolog 3, Disks large homolog 3, DLG 3, DLG3, DLG3_HUMAN, MPP3, MPP-3, KIAA1232, mKIAA1232, MRX 90, MRX, MRX90, NE Dlg, NEDLG, Neuroendocrine dlg, Neuroendocrine-DLG, OTTHUMP00000023475, OTTHUMP00000023476, OTTHUMP00000023477, SAP 102, SAP-102, SAP102, Synapse associated protein 102, Synapse-associated protein 102, XLMR, bA291O7.3, bA291O7.3.
Target Information: This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]