Description
Product Characteristics:
GAD-65 and GAD-67, glutamate decarboxylases, function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl- conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: GABA, GABAA receptor subunit beta-2, GABRB2, Gamma aminobutyric acid GABA A receptor, beta 2, Gamma aminobutyric acid A receptor beta 2, Gamma-aminobutyric acid receptor subunit beta-2, Gamma-aminobutyric-acid receptor subunit beta-2, GBRB2_HUMAN,
Target Information: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]