Description
Product Characteristics:
Voltage-dependent calcium channels are essential for the release of neurotransmitters. Cacna2d1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1), also known as CACNA2, CCHL2A, MHS3 or CACNL2A, is a 1,091 amino acid single-pass type I membrane protein that contains one VWFA domain and one cache domain. Expressed in skeletal muscle, aorta tissues and in the central nervous system (CNS), Cacna2d1 functions as an alpha-2/delta subunit of voltage-dependent calcium channels and plays an important role in calcium current density, as well as in excitation-contraction coupling. The Cacna2d1 precursor is proteolytically processed to produce two functional subunits, designated alpha-2-1 and delta-1, which are disulfide-linked to one another.
Subcellular location: Cell membrane
Synonyms: Calcium channel L type DHPR alpha 2 subunit, CA2D1_HUMAN, CACN A2, CACNA2, CACNA2D1, CACNL2A, Calcium channel L type alpha 2 polypeptide, Calcium channel voltage dependent alpha 2/delta subunit 1, CCHL2A, Dihydropyridine receptor alpha 2 subunit, Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit, Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta, H_DJ0560O14.1, L type calcium channel subunit alpha 2, MHS 3, MHS3, Voltage dependent calcium channel subunit alpha 2/delta 1, Voltage gated calcium channel subunit alpha 2/delta 1, Voltage-dependent calcium channel subunit delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, WUGSC:H_DJ0560O14.1.
Target Information: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]