Description
Product Characteristics:
Ubiquitin-dependent proteolysis mediates selective destruction of various cell cycle regulators, transcription factors and tumor suppressors. In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S proteasome. At specific stages of development, embryo- and tissue-specific components of the 26S proteasome form, facilitating proteolysis. 20S Proteasome ?, also designated macropain subunit C2 or PROS-30, is a prosomal protein involved in a non-lysosomal ATP/ubiquitin-dependent proteolytic pathway. The entire proteasome is composed of at least 15 non-identical subunits which form a highly-ordered ring-shaped structure.
Synonyms: 20S Proteasome 1, 30 kDa prosomal protein, HC 2, HC2, Macropain subunit C2, Macropain subunit nu, Multicatalytic endopeptidase complex subunit C2, NU antibody PROS 30, PROS-30, PROS30, Proteasome prosome macropain subunit alpha type 1, Proteasome alpha 1 subunit, Proteasome component C2, Proteasome nu chain, Proteasome subunit alpha type 1, Proteasome subunit alpha type I, Proteasome subunit alpha type-1, Proteasome subunit nu, Protein P30 33K, PSA1_HUMAN, PSC 2, PSC2, PSMA 1, psmA1.
Target Information: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]