Description
Product Characteristics:
The P2X receptor family is comprised of ligand-gated ion channels that allow for the increased permeability of calcium into the cell in response to extracellular ATP. The seven P2X receptors, P2X1-P2X7, form either homomeric or heteromeric channels or both. They are characterized by intracellular amino- and carboxy-termini. P2X receptors are expressed in a wide variety of tissues, including neurons, prostate, bladder, pancreas, colon, testis and ovary. The major function of the P2X receptors is to mediate synaptic transmissions between neurons and to other tissues via the binding of extracellular ATP, which acts as a neurotransmitter. The P2X receptors may be involved in the onset of necrosis or apoptosis after prolonged exposure to high concentrations of extracellular ATP.
Subcellular location: Cell membrane
Synonyms: ATP receptor, ATP receptor subunit, ionotropic ATP receptor P2X5, MGC47755, P2RX5, P2X purinoceptor 5, P2X5, P2X5R, Purinergic receptor, Purinergic receptor P2X ligand gated ion channel 5, P2RX5_HUMAN.
Target Information: Please see product details or send an inquiry to antibodies-online for additional target information