Description
Product Characteristics:
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 2 (MATH-2) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of Drosophila atonal gene. MATH-2 is a 337 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-2 takes place by embryonic day 11.5 and initially localizes to the wall of brain vesicles and in the spinal cord. It is expressed in the cortical plate and the mantle layer in the developing central nervous system, and is limited to the nervous system in adults. Adult mouse cerebrums produce a high level of MATH-2 RNA with lower levels in other neuronal tissues. Research studies suggest that MATH-2 may function as a trans-acting factor involved in the development and maintenance of the mammalian nervous system.
Subcellular location: Nucleus
Synonyms: Atoh 2, Atoh2, Atonal homolog 2, Atonal protein homolog 2, Atonal protein homolog2, bHLH a2 antibodybHLHa 2, bHLHa2, Class A basic helix-loop-helix protein 2, Helix loop helix protein mATH 2, Helix loop helix protein mATH2, MATH 2, Math2, NDF 6, NDF6, NDF6_HUMAN, Neuro D6, NeuroD6, Neurogenic dferentiation 6, Neurogenic dferentiation factor 6, Nex 1 antibodyNex 1m, Nex, Nex1, Nex1 m, Nex1m, Protein atonal homolog 2, Protein atonal homolog2.
Target Information: This gene is a member of the NEUROD family of basic helix-loop-helix transcription factors. The encoded protein may be involved in the development and differentiation of the nervous system. [provided by RefSeq, Nov 2012]