Description
Product Characteristics:
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012].
Synonyms: BLNK phospho Y84, p-BLNK phospho Y84, B cell adapter containing SH2 domain protein, B cell adapter containing Src homology 2 domain protein, B cell linker, B cell linker protein, B cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, B-cell linker protein, BASH, BASH, Bca, Bca, BLNK, BLNK s, BLNK_HUMAN, Cytoplasmic adapter protein, Ly 57, Ly-57, Ly57, Lymphocyte antigen 57, Lymphocyte antigen-57, Lyw 57, Lyw-57, Lyw57, MGC111051, SLP 65, SLP65, SLP-65, Src homology 2 domain containing leukocyte protein of 65 kDa.
Target Information: This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]