Description
Product Characteristics:
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Subcellular location: Cell membrane
Synonyms: LAR, LAR protein, LARFN5C, LARS, LCA homolog, Leukocyte antigen related LAR PTP receptor, Leukocyte antigen related, Leukocyte antigen related PTP receptor, Leukocyte antigen related tyrosine phosphatase, Leukocyte common antigen related, Protein Tyrosine Phosphatase Receptor Type F, Protein tyrosine phosphatase receptor type F polypeptide, Ptprf, PTPRF protein, PTPRF_HUMAN, Receptor linked protein tyrosine phosphatase LAR, Receptor type tyrosine protein phosphatase F, Receptor type tyrosine protein phosphatase F precursor, Receptor-type tyrosine-protein phosphatase F.
Target Information: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]