Description
Product Characteristics:
G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR154 (G-protein coupled receptor 154), also known as NPSR1 (neuropeptide S receptor), GPRA (G-protein coupled receptor for asthma susceptibility) or PGR14, is a 371 amino acid protein that is thought to play a role in autocrine or paracrine signaling pathways. Ubiquitously expressed, GPR154 exists as nine alternatively spliced isoforms. Defects in the gene encoding GPR154 is the cause of asthma-related traits type 2 (ASRT2).
Subcellular location: Cytoplasm, Cell membrane
Synonyms: ASRT2, G protein coupled receptor 154, G protein coupled receptor for asthma susceptibility, G protein coupled receptor PGR14, GPR 154, gpr154, GPRA, MVTR, Neuropeptide S receptor 1, Neuropeptide S receptor, nps receptor, NPSR 1, NPSR, NPSR1, PGR 14, PGR14, PGR-14, Vasopressin receptor related receptor 1, VRR 1, VRR1, NPSR1_HUMAN.
Target Information: This gene is a member of the G protein-coupled receptor 1 family and encodes a plasma membrane protein. Increased expression of this gene in ciliated cells of the respiratory epithelium and in bronchial smooth muscle cells is associated with asthma. Mutations in this gene have also been associated with this disease. Alternatively spliced variants which encode different protein isoforms have been described\, however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]