Description
Product Characteristics:
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.
Synonyms: E3 ubiquitin-protein ligase RNF19B, IBR domain containing 3, IBR domain-containing protein 3, IBRDC3, Natural killer lytic-associated molecule, NKLAM, RING finger protein 19B, RN19B_HUMAN, rnf19b.
Target Information: IBRDC3 is a cytolysis-associated transmembrane protein expressed in natural killer (NK) cells and T lymphocytes following cytokine stimulation (Kozlowski et al., 1999 [PubMed 10438909]).[supplied by OMIM, Mar 2008]