Description
Product Characteristics:
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21.This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008].
Synonyms: CK-19, CK 19, 40 kDa keratin intermediate filament, CK 19, Cytokeratin19, ck19, Cytokeratin 19, Cytokeratin-19, k19, k1cs, Keratin 19, Keratin type I 40 kD, Keratin type i 40kD, Keratin type I cytoskeletal 19, krt19, mgc15366, Cytokeratin 17, Cytokeratin 19, Cytokeratin 14, Cytokeratin 42, Cytokeratin 10, CK 19, CK 17, CK 14, CK 42, CK10, CK19/CK17/CK14/CK10/CK42, K1C17_HUMAN.
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