Description
Product Characteristics:
The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date (13). While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development (13). The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1 (Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3 (Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep). Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. In addition, ephrin-A2 (ELF-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk) (47).
Subcellular location: Cell membrane
Synonyms: Cek10, EK2, Embryonic kinase 2, EPH Like Tyrosine Kinase 2, EPH-like kinase 2, ephb3, EPHB3_HUMAN, Ephrin receptor EphB3, Ephrin type B receptor 3, Ephrin type-B receptor 3, ETK2, hEK2, Human Embryo Kinase 2, Mdk5, Sek4, TYRO6, Tyrosine protein kinase receptor HEK2, Tyrosine protein kinase TYRO6, Tyrosine-protein kinase TYRO6.
Target Information: Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]