Description
Product Characteristics:
The human homolog of the Drosophila lady bird late gene, LBX1, is specifically expressed in the developing central nervous system and musculoskeletal system. The LBX1 gene has a restrictive expression pattern in the dorsal portion of the mantle of the spinal cord and the hindbrain of the CNS. In the developing mouse and chicken musculoskeletal system, Lbx1 is expressed in migrating limb muscle precursor cells. In addition, Lbx1 may regulate migratory patterns of limb muscle cell precursors and may be essential to dorsal identification of forelimb muscles.
Subcellular location: Nucleus
Synonyms: Homeobox, HPX 6, HPX6 antibodyLady bird like homeobox, Ladybird homeobox 1, Ladybird homeobox homolog 1, Ladybird homeobox protein homolog 1, LBX 1, LBX 1H, LBX1H, Transcription factor LBX1, Transcription factor similar to D. melanogaster homeodomain protein lady bird late, LBX1_HUMAN.
Target Information: This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles. [provided by RefSeq, Jul 2008]