Description
Product Characteristics:
Gamma-aminobutyric acid type A (GABAA) receptors are members of the neurotransmitter ligand-gated ion channels that mediate neuronal inhibition on binding GABA. The effects of GABA on GABAA receptors are modulated by a range of therapeutically important drugs, including barbiturates, anaesthetics and benzodiazepines.
Subcellular location: Cell membrane
Synonyms: GABA A receptor beta 3 subunit, GABA alpha receptor beta 2 subunit, GABAA receptor beta 2 subunit, GABAA receptor beta 3 subunit, GABAA receptor subunit beta 2, GABAA receptor subunit beta 3, GABRB2, GABRB3, Gamma Aminobutyric Acid A receptor beta 3, Gamma Aminobutyric Acid receptor beta 2 subunit, Gamma aminobutyric acid receptor subunit beta 2, Gamma aminobutyric acid receptor subunit beta 3, Testis gamma aminobutyric acid receptor subunit beta 3, GBRB2_HUMAN.
Target Information: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]