Description
Product Characteristics:
Members of the myogenic determination family are basic helix-loop-helix (bHLH) proteins that can be separated into two classes, both of which work together to activate DNA transcription. Class A proteins include the ubiquitously expressed E-box binding factors, namely E2A, ITF-2 and HEB, while class B proteins, such as MyoD, myogenin and Neuro D (BETA2), are transiently expressed and exhibit a much more limited tissue distribution. Working in opposition to these positively acting factors are a specialized group of basic helix-loop-helix (bHLH) transcription factors that function as dominant negative regulators and are involved in cell lineage determination and differentiation. Neuro D2 (neurogenic differentiation 2), also known as NDRF, NEUROD2 or bHLHa1, is a 382 amino acid nuclear protein that contains one bHLH domain and functions to induce neurogenic differentiation, playing an important role in the maintenance and determination of cell fate.
Subcellular location: Nucleus
Synonyms: bHLHa1, Class A basic helix-loop-helix protein 1, class A basic helix loop helix protein 1, NDF2_HUMAN, NDR2, NDRF, Neuro-D2, NeuroD-related factor, NeuroD2, Neurogenic dferentiation factor 2, NDF2_HUMAN, neuroD related factor, NeuroD2, neurogenic basic helix loop helix protein, neurogenic dferentiation 2, Neurogenic dferentiation factor 2, neuronal dferentiation 2.
Target Information: This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates. [provided by RefSeq, Jul 2008]