Description
Product Characteristics:
GATA1 is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch from fetal hemoglobin production to adult hemoglobin.
Subcellular location: Nucleus
Synonyms: GATA1 phospho S142, p-GATA1 phospho S142, GATA1Ser142, GATA1, ERYF 1, ERYF1 antibody Erythroid transcription factor, Erythrold transcription factor 1, GATA 1, GATA binding factor 1, GATA binding protein 1, GF 1, GF1, Globin transcription factor 1, NF E1, NF E1 DNA binding protein, NFE 1, NFE1, GATA1_HUMAN, Erythroid transcription factor, Eryf1, GATA-binding factor 1, GATA-1, GF-1, NF-E1 DNA-binding protein.
Target Information: This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]