Description
Product Characteristics:
Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPs). The protein contains a 121 residue extracellular domain, a single transmembrane segment, and 2 tandem intracytoplasmic catalytic domains. The PTP alpha protein is ubiquitously expressed and may play a fundamental role in the physiology of all cells.
Subcellular location: Secreted, Cell membrane
Synonyms: PTP alpha phospho Y798, HEPTP, HLPR, HPTP alpha, HPTPA, HPTPalpha, Leukocyte common antigen related peptide, LRP, Protein tyrosine phosphatase alpha, Protein tyrosine phosphatase receptor type A, Protein tyrosine phosphatase receptor type alpha polypeptide, Protein tyrosine phosphate, Protein-tyrosine phosphatase alpha, PTPA, PTPalpha, PTPase alpha, PTPLCA related phosphatase, PTPRA, PTPRA_HUMAN, PTPRL 2, PTPRL2, PTRA, R PTP alpha, R-PTP-alpha, Receptor type tyrosine protein phosphatase alpha, Receptor-type tyrosine-protein phosphatase alpha, RPTPA, Tyrosine phosphatase alpha.
Target Information: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]