Description
Product Characteristics:
Required for renal tubular integrity.Tissue specificity: Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.
Subcellular location: Cytoplasm
Synonyms: JCK, NEK 8, NEK12A, NEK8, NEK8_HUMAN, Never in mitosis A-related kinase 8, NIMA-family kinase NEK8, NIMA-related kinase 12a, Nima-related protein kinase 12a, NimA-related protein kinase 8, Serine/threonine-protein kinase Nek8.
Target Information: This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans. [provided by RefSeq, Jul 2008]