Description
Product Characteristics:
RBM5 (RNA binding motif protein 5) is a nuclear SR related RNA binding protein which specifically binds poly(G) RNA homopolymers in vitro. It modulates both apoptosis and the cell cycle, and retards tumor formation.
Subcellular location: Nucleus
Synonyms: G15 antibody H37 antibody LUCA 15, LUCA15, Protein G15, RBM 5, Renal carcinoma antigen NY REN 9, RMB 5, RMB5, RNA binding mot protein 5, RNA binding protein 5, Tumor suppressor LUCA15, RBM5_HUMAN.
Target Information: This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]