Description
Product Characteristics: Clec1b acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Synonyms: Polyclonal Clec1b antibody, Anti-Clec1b antibody, C-type lectin domain family 1, member b antibody, 1810061I13Rik antibody, AI465458 antibody, Clec-2 antibody, Clec2 antibody, mCLEC-2 antibody.
Target Information: Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1\, MIM 602894) and NKG2D (KLRC4\, MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]