Description
Product Characteristics: Synonyms:
70 kDa Lamin antibody,Cardiomyopathy dilated 1A (autosomal dominant) antibody,CDCD1 antibody,CDDCantibody,Charcot Marie Tooth Disease Axonal Type 2B1 antibody,CMD1A antibody,CMT2B1 antibody,EMD2antibody,FPL antibody,FPLD antibody,HGPS antibody,IDC antibody,Lamin A/C antibody,Lamin A/C Isoform 1Precursor antibody,Lamin A/C Isoform 2 antibody,Lamin A/C Isoform 3 antibody,LDP1 antibody,LFPantibody,LGMD1B antibody,Limb girdle muscular dystrophy 1B (autosomal dominant) antibody,LMN 1 antibody,LMN Aantibody,LMN C antibody,LMN1 antibody,LMNA antibody,LMNC antibody,NY REN 32 antigen antibody,PRO1antibody,Progeria 1 (Hutchinson Gilford Type) antibody,Renal carcinoma antigen NY REN 32 antibody,Renalcarcinoma antigen NYREN32 antibody
Target Information: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]