Description
Product Characteristics:
Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.
Subcellular location: Cytoplasm
Synonyms: RAB guanine nucleotide exchange factor GEF 1, Rab5 GDP/GTP exchange factor, Rab5ef, Rabaptin 5 associated exchange factor for Rab5, Rabaptin-5-associated exchange factor for Rab5, Rabex 5, Rabex-5, RABGEF 1, Rabgef1, RABX 5, RABX5, RABX5_HUMAN, RAP1, Rin 2, Rin2.
Target Information: RABGEF1 forms a complex with rabaptin-5 (RABPT5\, MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A\, MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010]