Description
Product Characteristics: CD4 (cluster of differentiation 4) is a glycoprotein expressed on the surface of T helper cells, regulatory T cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and T4 (after the OKT4 monoclonal antibody that reacted with it) before being named CD4 in 1984. In humans, the CD4 protein is encoded by the CD4 gene. Synonyms: Monoclonal CD4 antibody, Anti-CD4 antibody, L3T4 antibody, CD4 antigen (p55) antibody, CD4+ Lymphocyte deficiency, included antibody, CD4_HUMAN antibody, CD4mut antibody, L3T4 antibody, Leu3 antibody, Ly-4 antibody, Lymphocyte antigen CD4 antibody, MGC165891 antibody, p55 antibody, T Cell Antigen T4 antibody, T cell antigen T4/LEU3 antibody, T cell differentiation antigen L3T4 antibody, T cell OKT4 deficiency, included antibody, T cell surface antigen T4/Leu 3 antibody, T cell surface antigen T4/Leu3 antibody, T Cell Surface Glycoprotein CD4 antibody, T-cell surface antigen T4/Leu-3 antibody, T-cell surface glycoprotein CD4 antibody, W3/25 antibody, W3/25 antigen antibody,.
Target Information: This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]