Description
Product Characteristics:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
Subcellular location: Cell membrane
Synonyms: ABC, ABC14, EST45597, ABC 14, ABC-14, ABCB 6, ABCB-6, PRP, UMAT, ABC transporter umat, MTABC3, Mt-ABC transporter 3, umat, Mitochondrial precursor, Mitochondrial ABC transporter 3, Mitochondrial abc protein 3, ATP-binding cassette, sub-family B, member 6, mitochondrial precursor, ATP binding cassette, sub family B MDR/TAP, member 6, P glycoprotein related protein, Abcb6, ABCB6_HUMAN, ATP binding cassette sub family B member 6, mitochondrial precursor, ATP-binding cassette sub-family B member 6, Mitochondrial ABC transporter 3, mitochondrial, Mt ABC transporter 3, P-glycoprotein-related protein, Ubiquitously-expressed mammalian ABC half transporter, UMAT, Ubiquitously expressed mammalian ABC half transporter.
Target Information: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. [provided by RefSeq, Jul 2008]