Description
Product Characteristics:
IKZF3 belongs to the Ikaros family of zinc-finger proteins. Members of this family are transcription factors that play an important role in the regulation of lymphocyte differentiation. They are involved in the control of gene expression and when associated with nuclear complexes, participate in nucleosome remodeling. IKZF3 is important in the regulation of B lymphocyte proliferation and differentiation.
Subcellular location: Cytoplasm, Nucleus
Synonyms: Aiolos, IKAROS family zinc finger 3 Aiolos, IKAROS family zinc finger 3, Ikaros family zinc finger protein 3, IKZF 3, IKZF3, IKZF3_HUMAN, Zinc finger protein Aiolos, Zinc finger protein subfamily 1A 3 Aiolos, Zinc finger protein subfamily 1A 3, ZNFN1A3.
Target Information: This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]