Description
Product Characteristics: ZMIZ1 increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation. Synonyms: Polyclonal ZMIZ1 antibody, Anti-ZMIZ1 antibody, zinc finger, MIZ-type containing 1 antibody, FLJ13541 antibody, KIAA1224 antibody, MIZ antibody, RAI17 antibody, Zimp10 antibody, hZIMP10 antibody.
Target Information: This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]