Description
Product Characteristics: The antibody reacts with a 120 kDa single chain membrane glycoprotein specific for the CD6 antigen. The antigen is found on >80% normal mature T cells and a sub-population of B cells in peripheral blood. The antigen also exhibits weak expression on cortical thymocytes and the majority of chronic B lymphocytic leukaemias
Target Information: This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]