Description
Product Characteristics:
Putative E3 ubiquitin-protein ligase. May participate in methylation-dependent transcriptional regulation. Binds to inverted 5'-CCAAT-3' box 2 in the TOP2A promoter, and activates TOP2A expression. Important for G1/S transition. May be involved in DNA repair and chromosomal stability.Tissue specificity:Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. UHRF2 is an E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. E3 SUMO-, but not ubiquitin-, protein ligase for ZNF131.
Subcellular location: Nucleus
Synonyms: HuNp95, ICBP90, Inverted CCAAT box binding protein of 90 kDa, Inverted CCAAT box binding protein, 90-kD, Inverted CCAAT box-binding protein of 90 kDa, Liver regeneration-related protein LRRG126, NP95, Nuclear phosphoprotein, 95-KD, Nuclear protein 95, Nuclear zinc finger protein Np95, RING finger protein 106, RNF106, Transcription factor ICBP90, Ubiquitin like containing PHD and RING finger domains protein 1, Ubiquitin like PHD and RING finger domain containing protein 1, Ubiquitin-like PHD and RING finger domain-containing protein 1, Ubiquitin-like protein containing PHD and RING finger domains 1, Ubiquitin-like with PHD and ring finger domains 1, Ubiquitin-like, containing PHD and RING finger domains, 1, Ubiquitin-like-containing PHD and RING finger domains protein 1, UHRF1, UHRF1_HUMAN, E3 ubiquitin-protein ligase UHRF1, Ubiquitin-like-containing PHD and RING finger domains protein 2, UHRF2, UHRF2_HUMAN, E3 ubiquitin-protein ligase UHRF2.
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