Description
Product Characteristics:
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
Subcellular location: Cell membrane
Synonyms: CNAIP, bK126B4.4, NFAT activation molecule 1, Calcineurin/NFAT-activating ITAM-containing protein, NFAT-activating protein with ITAM motif 1, NFAM1
Target Information: The protein encoded by this gene is a type I membrane receptor that activates cytokine gene promoters such as the IL-13 and TNF-alpha promoters. The encoded protein contains an immunoreceptor tyrosine-based activation motif (ITAM) and is thought to regulate the signaling and development of B-cells. [provided by RefSeq, Jul 2008]