Description
Product Characteristics:
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: Apoptosis regulator BCL W, Apoptosis regulator Bcl-W, B2CL2_HUMAN, BCL 2 Like 2, Bcl 2 like 2 protein, Bcl 2L2, BCL W, Bcl-2-like protein 2, Bcl2 L2, BCL2 like 2, BCL2 like 2 protein, Bcl2-L-2, Bcl2l2, BCLW.
Target Information: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]