Description
Product Characteristics:
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
Subcellular location: Secreted
Synonyms: A proliferation inducing ligand, A proliferation-inducing ligand, APRIL, CD 256, CD256, CD256 antigen, Ligand, proliferation inducing ligand APRIL, TALL 2, TALL-2, TALL2, TNF and APOL related leukocyte expressed ligand 2, TNF related death ligand 1, TNF related death ligand, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TNF13_HUMAN, TNFSF 13, TNFSF13, TNFSF13 protein, TRDL 1, TRDL-1, TRDL1, Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor related death ligand, Tumor necrosis factor related death ligand 1, Tumor necrosis factor superfamily member 13, TWE PRIL, ZTNF2.
Target Information: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified\, such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]