Description
Product Characteristics:
MARCKS, (Myristoylated Alanine-Rich C Kinase Substrate), is a member of a family of calmodulin binding proteins and is a major substrate for phosphorylation by protein kinase C (PKC). The phosphorylation of Ser152/156 can be used as a measure of PKC activation. Phosphorylation of Ser152/156 modulates the binding of MARCKS to calmodulin.
Subcellular location: Cytoplasm, Cell membrane
Synonyms: 80 kDa protein, 80K L, 80K L protein, 80K-L protein, 80KL, 81 kDa protein, light chain, light chain, MACS, MARCKS, MARCS, MARCS_RAT, MGC52672, myristoylated alanine rich C kinase substrate, Myristoylated alanine rich protein kinase C substrate MARCKS, 80K L, Myristoylated alanine rich protein kinase C substrate, Myristoylated alanine-rich C-kinase substrate, Phosphomyristin, PKCSL, PRKCSL, protein kinase C substrate 80 kDa protein light chain, Protein kinase C substrate.
Target Information: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]