Description
Product Characteristics:
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Subcellular location: Cytoplasm, Nucleus
Synonyms: C10orf66, bA18I14.5, CUE domain-containing protein 2, CUEDC2, HOYS6
Target Information: Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation (By similarity)